The performance of endodontic instruments is critically influenced by their ability to withstand cyclic fatigue, especially during root canal treatment in curved canals. This study investigates the cyclic fatigue resistance of the TruNatomy file system, a new generation of nickel-titanium (NiTi) endodontic instruments with different rotary file systems. The objective of this study was to conduct a systematic review of the literature and meta-analysis to evaluate and compare cyclic fatigue resistance of TruNatomy rotary endodontic file versus different rotary endodontic file systems. Research question was formulated based on the population, intervention, comparison, and outcomes strategy. A comprehensive electronic literature search was conducted through Cochrane, PubMed, and Google scholar using MeSH words, text words, and Boolean operators, independently by two reviewers. Based on the specified inclusion and exclusion criteria, the selected articles were subjected to quality assessment and the risk of bias (ROB) was evaluated. Risk of Bias assessment for invitro studies done in accordance with the Quality Assessment Tool for in Vitro Studies (QUIN Tool). Initially, 82 studies recovered, 8 articles were selected for systematic review and 8 articles could be included in the Meta-analysis. Among all the file systems - The number of cycles required to fail was significantly greater in the TruNatomy group than in the other file systems with standardized mean difference of 1.343 (95% CI = 0.645 to 2.042; p<0>
Keywords: Cyclic fatigue resistance, Nickel ? titanium file, TruNatomy, Canal curvature